Research
Mixed
Immunosenescence, characterized by a decline in immune cell function and an increase in pro-inflammatory cytokine secretion, impairs the clearance of senescent cells and pathogens, exacerbating aging.
Immune function declines with age, leading to increased susceptibility to infection and chronic inflammation. Maintaining immune health through vaccination, stress management, and nutrient adequacy is crucial for older adults.
StrongSupportsHIGH confidence
chronic inflammation accelerates the senescence of immune cells, resulting in weakened immune function and an inability to clear senescent cells and inflammatory factors
Why this rating
Supported by detailed descriptions of immune cell changes across multiple cell types.
Source
Inflammation and aging: signaling pathways and intervention therapies
Xia Li et al. · Signal Transduction and Targeted Therapy · 2023
DOI 10.1038/s41392-023-01502-8
narrative_reviewCited 1,228×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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