Research
Mixed
Satellite cells are the essential progenitor cells for adult skeletal muscle regeneration, residing in a quiescent state within the niche until activated by injury or other stimuli to differentiate into new muscle fibers.
For long-term muscle health and repair, the activation of satellite cells is crucial. While resistance training is the primary stimulus, the biological reality is that these cells must be activated to contribute to muscle growth and repair.
StrongSupportsHIGH confidence
In mature skeletal muscle, this function is provided by the satellite cells... Unless activated by muscle injury or other stimuli, their niche allows adult satellite cells to persist in a quiescent, non-proliferative state...
Why this rating
Well-established consensus in the field, supported by extensive genetic and cellular studies cited.
Source
Building Muscle: Molecular Regulation of Myogenesis
C. Florian Bentzinger et al. · Cold Spring Harbor Perspectives in Biology · 2012
narrative_reviewCited 1,178×
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