Research
Mixed
Extrinsic morphogen gradients (Wnt, Shh, BMP) play a critical role in patterning the somite and regulating the expression of key myogenic transcription factors (MyoD, Myf5) during embryonic development.
Embryonic muscle development is heavily influenced by environmental signals (morphogens) that guide cell fate. This highlights the complexity of muscle biology, though direct application to adult training is limited.
StrongSupportsHIGH confidence
Members of the Wnt family of proteins are of particular importance for the formation of the dermomyotome and myotome... Shh is also involved in the positive specification of muscle progenitors... BMP inhibits expression of certain myogenic genes.
Why this rating
Supported by extensive genetic knockout and mutant studies.
Source
Building Muscle: Molecular Regulation of Myogenesis
C. Florian Bentzinger et al. · Cold Spring Harbor Perspectives in Biology · 2012
narrative_reviewCited 1,178×
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