Mixed
NAD+ metabolism regulates physiological processes and its deficiency contributes to metabolic diseases, cancer, aging, and neurodegeneration.
Maintaining healthy NAD+ levels is crucial for preventing age-related diseases. While the paper focuses on mechanisms, lifestyle factors like exercise and caloric restriction are known to support NAD+ homeostasis. Consider discussing NAD+ precursors with a healthcare provider if you are interested in therapeutic interventions.
Prolonged disequilibrium of NAD+ metabolism disturbs the physiological functions, resulting in diseases including metabolic diseases, cancer, aging and neurodegeneration disorder.
Why this rating
This is a review article summarizing multiple studies, providing strong mechanistic evidence but lacking direct clinical trial data for specific interventions.
Source
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Na Xie et al. · Signal Transduction and Targeted Therapy · 2020
DOI 10.1038/s41392-020-00311-7
More from this paper
- NAD+ serves as a co-substrate for enzymes like sirtuins and PARPs, and as a nucleotide analog in DNA ligation, impacting energy metabolism, DNA repair, and gene expression.Strong
- NAD+ deficiency contributes to a spectrum of diseases including metabolic diseases, cancer, aging and neurodegeneration disorders.Good
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