Research
Mixed
NAD+ deficiency contributes to a spectrum of diseases including metabolic diseases, cancer, aging and neurodegeneration disorders.
Maintaining healthy NAD+ levels is crucial for preventing age-related diseases. While the paper focuses on mechanisms, lifestyle factors like exercise and caloric restriction are known to support NAD+ homeostasis. Consider discussing NAD+ precursors with a healthcare provider if you are interested in therapeutic interventions.
GoodSupportsHIGH confidence
NAD+ deficiency, however, contributes to a spectrum of diseases including metabolic diseases, cancer, aging and neurodegeneration disorders.
Why this rating
This is a review article summarizing multiple studies.
Source
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Na Xie et al. · Signal Transduction and Targeted Therapy · 2020
DOI 10.1038/s41392-020-00311-7
narrative_reviewCited 1,005×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- NAD+ serves as a co-substrate for enzymes like sirtuins and PARPs, and as a nucleotide analog in DNA ligation, impacting energy metabolism, DNA repair, and gene expression.Strong
- NAD+ metabolism regulates physiological processes and its deficiency contributes to metabolic diseases, cancer, aging, and neurodegeneration.Good
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