Research
Mixed
NAD+ serves as a co-substrate for enzymes like sirtuins and PARPs, and as a nucleotide analog in DNA ligation, impacting energy metabolism, DNA repair, and gene expression.
Understanding NAD+ roles helps explain why lifestyle factors like exercise and diet are important for healthspan. NAD+ is not just for energy but also for DNA repair and gene regulation.
StrongSupportsHIGH confidence
Through these activities, NAD+ impact energy metabolism, DNA repair, epigenetic modification, inflammation, circadian rhythm and stress resistance.
Why this rating
This is a review article summarizing multiple studies, providing strong mechanistic evidence.
Source
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Na Xie et al. · Signal Transduction and Targeted Therapy · 2020
narrative_reviewCited 1,005×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →