Research
Mixed
NAD+ serves as a co-substrate for enzymes like sirtuins and PARPs, and as a nucleotide analog in DNA ligation, impacting energy metabolism, DNA repair, and gene expression.
Understanding NAD+ roles helps explain why lifestyle factors like exercise and diet are important for healthspan. NAD+ is not just for energy but also for DNA repair and gene regulation.
StrongSupportsHIGH confidence
Through these activities, NAD+ impact energy metabolism, DNA repair, epigenetic modification, inflammation, circadian rhythm and stress resistance.
Why this rating
This is a review article summarizing multiple studies, providing strong mechanistic evidence.
Source
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Na Xie et al. · Signal Transduction and Targeted Therapy · 2020
DOI 10.1038/s41392-020-00311-7
narrative_reviewCited 1,005×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →