Research

Micronutrients & recovery

Low-dose supplementation with marine n-3 fatty acids (EPA-DHA) or plant-derived alpha-linolenic acid (ALA) does not significantly reduce the rate of major cardiovascular events in patients who have had a myocardial infarction and are receiving state-of-the-art standard therapy.

If you have had a heart attack, taking low-dose fish oil (EPA-DHA) or flaxseed oil (ALA) supplements will not significantly lower your risk of another major cardiovascular event, provided you are already taking your prescribed heart medications (blood pressure, blood thinner, and cholesterol drugs). Do not rely on these supplements as a substitute for standard medical therapy.

StrongRefutesHIGH confidence
Low-dose supplementation with EPA–DHA or ALA did not significantly reduce the rate of major cardiovascular events among patients who had had a myocardial infarction and who were receiving state-of-the-art antihypertensive, antithrombotic, and lipid-modifying therapy.
Daan Kromhout et al. · New England Journal of Medicine · 2010

Why this rating

High-quality evidence from a large-scale (N=4837), double-blind, placebo-controlled randomized trial with long follow-up (40 months).

Source

n–3 Fatty Acids and Cardiovascular Events after Myocardial Infarction

Daan Kromhout et al. · New England Journal of Medicine · 2010

rct · n=4837Cited 927×
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