Micronutrients & recovery
Omega-3 LC-PUFAs (EPA/DHA) lower fasting plasma triglyceride (TG) levels by 29% in individuals with levels >150 mg/dL when taken at doses of 3.4–4 g/day, primarily by inhibiting de novo lipogenesis via SREBP1c regulation.
If your triglycerides are high (over 150 mg/dL), standard fish oil doses won't fix it. You likely need a therapeutic dose of 3.4–4 grams of EPA/DHA daily to see a ~29% drop in triglycerides. Consult a doctor for this high-dose protocol, as it is distinct from general health maintenance doses.
Taking EPA and/or DHA in doses of 3.4–4 g/day have been shown to decrease TG levels by an average of 29% in individuals with levels higher than 150 mg/dL.
Why this rating
The paper cites consistent findings across studies for this specific high-dose effect, distinguishing it from mixed results in lower-dose cardiovascular outcome trials.
Source
Significance of long chain polyunsaturated fatty acids in human health
Rafael Zárate et al. · Clinical and Translational Medicine · 2017
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →