Research
Micronutrients & recovery
Omega-3 LC-PUFAs exert anti-inflammatory effects by generating specialized pro-resolving mediators (SPMs) like resolvins, protectins, and maresins, which actively promote the resolution of inflammation rather than just suppressing it.
Omega-3s do more than just reduce swelling; they help your body actively resolve inflammation and return to normal function through specialized mediators called SPMs. This supports long-term health in autoimmune and inflammatory conditions.
GoodSupportsHIGH confidence
These pro-resolving lipid mediators, together with the above mentioned resolvins, and the anti-inflammatory lipoxins, have been grouped together as specialized pro-resolving mediators (SPM).
Why this rating
Well-established biochemical pathway described in detail.
Source
Significance of long chain polyunsaturated fatty acids in human health
Rafael Zárate et al. · Clinical and Translational Medicine · 2017
DOI 10.1186/s40169-017-0153-6
narrative_reviewCited 545×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Omega-3 LC-PUFAs (EPA/DHA) lower fasting plasma triglyceride (TG) levels by 29% in individuals with levels >150 mg/dL when taken at doses of 3.4–4 g/day, primarily by inhibiting de novo lipogenesis via SREBP1c regulation.Good
- Increasing dietary intake of omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) and maintaining an omega-6/omega-3 ratio of 2–4:1 is associated with a reduced risk of breast, prostate, colon, and renal cancers.Moderate
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →