Research
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Calorie restriction (CR) attenuates the age-related upregulation of proinflammatory cytokines (NF-κB, IL-β, IL-6, and TNF-α), serving as a primary intervention to counteract inflamm-aging.
Adopting a calorie-restricted diet with adequate nutrients is a proven strategy to reduce chronic inflammation associated with aging. This involves eating less than your maintenance calories while ensuring you get all necessary vitamins and minerals, which helps lower inflammatory markers like IL-6 and TNF-α.
ModerateSupportsMEDIUM confidence
The age-related upregulation of NF-κB, IL-β, IL-6, and TNF-α in the proinflammatory states of the aging process is attenuated by CR [67].
Why this rating
The paper is a review citing multiple studies; specific human trial data is not provided in this text.
Source
An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment
Shijin Xia et al. · Journal of Immunology Research · 2016
DOI 10.1155/2016/8426874
narrative_reviewCited 531×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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