Research
Mixed
Resveratrol acts as a SIRT1 activator to inhibit NF-κB activation and suppress proinflammatory molecules (IL-1β, IL-6) in a dose-dependent manner, thereby inhibiting inflamm-aging.
Resveratrol is a supplement that activates SIRT1, which helps turn off inflammatory pathways like NF-κB. While effective in cell studies, specific dosing for humans is not defined in this review, so consult a healthcare provider before use.
ModerateSupportsMEDIUM confidence
Resveratrol effectively inhibits the activation of proinflammatory factors by activating SIRT1, leading to the deacetylation of NF-κB p-65 and subsequent downregulation of TNF-α-induced COX-2 and MMP expression [58].
Why this rating
Based on cell line studies (3T3 cells) and general review of mechanisms; human clinical efficacy for longevity is not established in this text.
Source
An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment
Shijin Xia et al. · Journal of Immunology Research · 2016
DOI 10.1155/2016/8426874
narrative_reviewCited 531×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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