Energy balance
Chronic exposure to high concentrations of fatty acids (lipid overload) inhibits AMPK activity, primarily through ceramide-dependent activation of protein phosphatase 2A (PP2A), contributing to insulin resistance and metabolic syndrome.
Excessive intake of fatty acids, particularly saturated fats like palmitate, can inhibit AMPK activity via ceramide and phosphatase pathways. This inhibition is linked to insulin resistance and metabolic syndrome. Managing lipid intake is crucial for maintaining healthy energy sensing.
It was reported that palmitate inhibited AMPK in endothelial cells via ceramide-dependent PP2A activation (Wu et al., 2007). Interestingly, AMPK inhibition by PP2C upregulation accounted for decreased AMPK activity in the heart of obese rodents with cardiac lipotoxicity (Wang and Unger, 2005).
Why this rating
The paper cites multiple studies in rodent models and cell lines showing consistent inhibition, though human clinical data is less explicit in this specific review.
Source
AMPK inhibition in health and disease
Benoı̂t Viollet et al. · Critical Reviews in Biochemistry and Molecular Biology · 2010
DOI 10.3109/10409238.2010.488215
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