Research
Energy balance
Glycogen accumulation allosterically inhibits AMPK activity by binding to its glycogen-binding domain, particularly when glycogen has high branching content.
High muscle glycogen levels can allosterically inhibit AMPK activity, particularly when glycogen has high branching content. This inhibition may help prevent further glycogen synthesis. Balancing glycogen levels is important for metabolic regulation.
ModerateSupportsMEDIUM confidence
Glycogen preparations with high branching content were found to cause allosteric inhibition of AMPK, due to its binding to the glycogen-binding domain (McBride et al., 2009).
Why this rating
The paper notes paradoxes and conflicting studies, suggesting this mechanism is context-dependent.
Source
AMPK inhibition in health and disease
Benoı̂t Viollet et al. · Critical Reviews in Biochemistry and Molecular Biology · 2010
DOI 10.3109/10409238.2010.488215
narrative_reviewCited 376×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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