Research
Micronutrients & recovery
CoQ10 supplementation (100-300 mg/day) reduces inflammatory markers (TNF-α, IL-6) in patients with metabolic diseases, rheumatoid arthritis, and other inflammatory conditions.
If you have chronic inflammation, metabolic syndrome, or rheumatoid arthritis, taking 60-500mg of CoQ10 daily may help lower inflammatory markers like TNF-α and IL-6. This is particularly relevant if you have low baseline CoQ10 levels.
GoodSupportsHIGH confidence
Administration of CoQ10 in doses ranging from 60 to 500 mg/day for a 1-week to 4-month intervention period significantly decreased production of inflammatory cytokines. The authors also surmised that CoQ10 supplementation decreased pro-inflammatory cytokines and inflammatory markers in the elderly with low CoQ10 levels (Fan et al., 2017).
Why this rating
Based on meta-analyses and multiple RCTs, though the paper notes inconsistencies in trial designs.
Source
Coenzyme Q10 Supplementation in Aging and Disease
Juan Diego Hernández‐Camacho et al. · Frontiers in Physiology · 2018
DOI 10.3389/fphys.2018.00044
narrative_reviewCited 351×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- CoQ10 supplementation (100-300 mg/day) improves mitochondrial function and reduces cardiovascular mortality in elderly populations with low baseline CoQ10 levels, particularly when combined with selenium.Good
- CoQ10 supplementation (2400 mg/day) is safe and well-tolerated in patients with early-stage Huntington's disease, but does not slow functional decline.Good
- CoQ10 supplementation (100-300 mg/day) improves semen parameters (concentration, motility, morphology) in men with idiopathic male infertility.Moderate
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →