Research
Mixed
Lymphocyte proportion in skeletal muscle is lower in young females compared to other demographic groups (young males, old males, old females).
Young women may have distinct immune cell profiles in muscle compared to men or older women. This does not change training advice but highlights biological differences in immune response.
GoodQualifiesHIGH confidence
We also find that the lymphocyte proportion (LV45), consisting of NK cells, T cells, and B cells genesets, is lower in the young female group than in any other group (old female, young male, and old male)
Why this rating
Statistically significant difference (p=0.00056) found via computational deconvolution of a large dataset.
Source
Single-cell transcriptional profiles in human skeletal muscle
Aliza B. Rubenstein et al. · Scientific Reports · 2020
DOI 10.1038/s41598-019-57110-6
mechanism_onlyCited 336×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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