Research
Mixed
Skeletal muscle contains a novel FBN1+ fibro-adipogenic progenitor (FAP) subtype in humans, which is also present in mice and may contribute to heterotopic ossification.
This is a basic science finding. The FBN1+ FAP subtype may play a role in bone formation within muscle (heterotopic ossification) after injury.
StrongSupportsVERY_HIGH confidence
The human FBN1+ FAP cell subtype is novel and a corresponding FBN1+ FAP cell type was also found in single cell RNA-seq analysis in mouse.
Why this rating
Single-cell RNA-seq validation in both human and mouse tissues.
Source
Single-cell transcriptional profiles in human skeletal muscle
Aliza B. Rubenstein et al. · Scientific Reports · 2020
DOI 10.1038/s41598-019-57110-6
mechanism_onlyCited 336×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Resistance exercise training increases the proportion of endothelial cells and pericytes in human skeletal muscle, while acute resistance exercise increases the proportion of neutrophils.Good
- Lymphocyte proportion in skeletal muscle is lower in young females compared to other demographic groups (young males, old males, old females).Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →