Research
Mixed
Skeletal muscle contains a novel FBN1+ fibro-adipogenic progenitor (FAP) subtype in humans, which is also present in mice and may contribute to heterotopic ossification.
This is a basic science finding. The FBN1+ FAP subtype may play a role in bone formation within muscle (heterotopic ossification) after injury.
StrongSupportsVERY_HIGH confidence
The human FBN1+ FAP cell subtype is novel and a corresponding FBN1+ FAP cell type was also found in single cell RNA-seq analysis in mouse.
Why this rating
Single-cell RNA-seq validation in both human and mouse tissues.
Source
Single-cell transcriptional profiles in human skeletal muscle
Aliza B. Rubenstein et al. · Scientific Reports · 2020
mechanism_onlyCited 336×
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