Research
Micronutrients & recovery
Manipulation of specific branches of methionine metabolism, including the methionine cycle, transsulfuration pathway, and polyamine biosynthesis, can extend lifespan.
Targeting specific metabolic pathways involved in methionine metabolism, such as the transsulfuration pathway or polyamine biosynthesis, may offer longevity benefits. This can be achieved through genetic manipulation or dietary interventions that affect these pathways.
GoodSupportsHIGH confidence
Manipulation of each of these branches extends lifespan; however, the interplay between MetR and these branches during regulation of lifespan is not well understood.
Why this rating
Supported by multiple studies showing lifespan extension via specific genetic or dietary manipulations of these pathways.
Source
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
Andrey A. Parkhitko et al. · Aging Cell · 2019
DOI 10.1111/acel.13034
narrative_reviewCited 286×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Methionine restriction (MetR) extends lifespan across multiple species, including yeast, worms, flies, and mammals, by modulating methionine metabolism pathways and methyltransferase activity.Good
- Regulation of methyltransferases and the SAM/SAH ratio plays a crucial role in lifespan extension by methionine restriction.Good
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →