Research
Micronutrients & recovery
Manipulation of specific branches of methionine metabolism, including the methionine cycle, transsulfuration pathway, and polyamine biosynthesis, can extend lifespan.
Targeting specific metabolic pathways involved in methionine metabolism, such as the transsulfuration pathway or polyamine biosynthesis, may offer longevity benefits. This can be achieved through genetic manipulation or dietary interventions that affect these pathways.
GoodSupportsHIGH confidence
Manipulation of each of these branches extends lifespan; however, the interplay between MetR and these branches during regulation of lifespan is not well understood.
Why this rating
Supported by multiple studies showing lifespan extension via specific genetic or dietary manipulations of these pathways.
Source
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
Andrey A. Parkhitko et al. · Aging Cell · 2019
narrative_reviewCited 286×
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