Research
Micronutrients & recovery
Regulation of methyltransferases and the SAM/SAH ratio plays a crucial role in lifespan extension by methionine restriction.
Maintaining a healthy balance of SAM and SAH levels may be important for longevity. This can be influenced by dietary methionine intake and genetic factors affecting methionine metabolism.
GoodSupportsHIGH confidence
A potential mechanism linking the activity of methionine metabolism and lifespan is regulation of production of the methyl donor S-adenosylmethionine, which, after transferring its methyl group, is converted to S-adenosylhomocysteine.
Why this rating
Supported by multiple studies showing lifespan extension via manipulation of methyltransferases and SAM/SAH levels.
Source
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
Andrey A. Parkhitko et al. · Aging Cell · 2019
DOI 10.1111/acel.13034
narrative_reviewCited 286×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Methionine restriction (MetR) extends lifespan across multiple species, including yeast, worms, flies, and mammals, by modulating methionine metabolism pathways and methyltransferase activity.Good
- Manipulation of specific branches of methionine metabolism, including the methionine cycle, transsulfuration pathway, and polyamine biosynthesis, can extend lifespan.Good
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