Research
Micronutrients & recovery
Regulation of methyltransferases and the SAM/SAH ratio plays a crucial role in lifespan extension by methionine restriction.
Maintaining a healthy balance of SAM and SAH levels may be important for longevity. This can be influenced by dietary methionine intake and genetic factors affecting methionine metabolism.
GoodSupportsHIGH confidence
A potential mechanism linking the activity of methionine metabolism and lifespan is regulation of production of the methyl donor S-adenosylmethionine, which, after transferring its methyl group, is converted to S-adenosylhomocysteine.
Why this rating
Supported by multiple studies showing lifespan extension via manipulation of methyltransferases and SAM/SAH levels.
Source
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
Andrey A. Parkhitko et al. · Aging Cell · 2019
narrative_reviewCited 286×
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