Hormonal
Nitric oxide (NO) bioavailability is significantly diminished in states of obesity and insulin resistance due to reduced NOS3 expression, impaired NOS3 activity, and increased NO quenching by reactive oxygen species.
If you have obesity or insulin resistance, your body's natural nitric oxide signaling is likely impaired, contributing to fat storage and metabolic issues. This isn't just about willpower; it's a molecular dysfunction. Strategies that support endothelial health and NO production (like exercise, which increases shear stress on blood vessels) may help restore this regulation.
NO bioavailability is decreased in animal models of obesity and diabetes [116,117] and in obese and diabetic humans [118,119].
Why this rating
The paper is a comprehensive review citing numerous animal and human studies, though it does not present new primary clinical trial data.
Source
Regulation of obesity and insulin resistance by nitric oxide
Brian E. Sansbury et al. · Free Radical Biology and Medicine · 2014
DOI 10.1016/j.freeradbiomed.2014.05.016
More from this paper
- Increasing nitric oxide output has remarkable effects on reducing obesity and improving insulin resistance.Good
- Nitric oxide increases food intake, acting as a pro-feeding signal in the central nervous system.Good
- NOS3 (endothelial nitric oxide synthase) has antiobesogenic effects, while NOS2 (inducible nitric oxide synthase) promotes insulin resistance.Good
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