Research
Hormonal
Increasing nitric oxide output has remarkable effects on reducing obesity and improving insulin resistance.
Boosting nitric oxide levels (e.g., through exercise which increases blood flow/shear stress) can help combat obesity and insulin resistance by improving metabolic regulation.
GoodSupportsHIGH confidence
increasing NO output has remarkable effects on obesity and insulin resistance.
Why this rating
Review of multiple studies showing antiobesogenic effects of NOS3 and NO donors.
Source
Regulation of obesity and insulin resistance by nitric oxide
Brian E. Sansbury et al. · Free Radical Biology and Medicine · 2014
DOI 10.1016/j.freeradbiomed.2014.05.016
narrative_reviewCited 270×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Nitric oxide (NO) bioavailability is significantly diminished in states of obesity and insulin resistance due to reduced NOS3 expression, impaired NOS3 activity, and increased NO quenching by reactive oxygen species.Good
- Nitric oxide increases food intake, acting as a pro-feeding signal in the central nervous system.Good
- NOS3 (endothelial nitric oxide synthase) has antiobesogenic effects, while NOS2 (inducible nitric oxide synthase) promotes insulin resistance.Good
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