Research
Hormonal
NOS3 (endothelial nitric oxide synthase) has antiobesogenic effects, while NOS2 (inducible nitric oxide synthase) promotes insulin resistance.
Not all nitric oxide is created equal. NOS3 is beneficial for obesity, while NOS2 (often driven by inflammation) worsens insulin resistance. Targeting the right pathway is crucial.
GoodSupportsHIGH confidence
Antiobesogenic effects of NOS3... NOS2 promotes insulin resistance.
Why this rating
Review of genetic and pharmacological interventions.
Source
Regulation of obesity and insulin resistance by nitric oxide
Brian E. Sansbury et al. · Free Radical Biology and Medicine · 2014
DOI 10.1016/j.freeradbiomed.2014.05.016
narrative_reviewCited 270×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Nitric oxide (NO) bioavailability is significantly diminished in states of obesity and insulin resistance due to reduced NOS3 expression, impaired NOS3 activity, and increased NO quenching by reactive oxygen species.Good
- Increasing nitric oxide output has remarkable effects on reducing obesity and improving insulin resistance.Good
- Nitric oxide increases food intake, acting as a pro-feeding signal in the central nervous system.Good
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