Research
Adherence
Nitric oxide increases food intake, acting as a pro-feeding signal in the central nervous system.
Nitric oxide plays a dual role: it helps burn energy but also stimulates hunger. This complexity means simply boosting NO might not always lead to weight loss if it significantly increases appetite.
GoodQualifiesHIGH confidence
NO increases food intake.
Why this rating
Cited studies show NO's role in increasing food intake.
Source
Regulation of obesity and insulin resistance by nitric oxide
Brian E. Sansbury et al. · Free Radical Biology and Medicine · 2014
DOI 10.1016/j.freeradbiomed.2014.05.016
narrative_reviewCited 270×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Nitric oxide (NO) bioavailability is significantly diminished in states of obesity and insulin resistance due to reduced NOS3 expression, impaired NOS3 activity, and increased NO quenching by reactive oxygen species.Good
- Increasing nitric oxide output has remarkable effects on reducing obesity and improving insulin resistance.Good
- NOS3 (endothelial nitric oxide synthase) has antiobesogenic effects, while NOS2 (inducible nitric oxide synthase) promotes insulin resistance.Good
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →