Research
Mixed
Genetic ablation of senescent cells using the INK-ATTAC transgenic system delays age-related phenotypes and extends lifespan in mice.
This is a foundational scientific finding showing that removing senescent cells can extend life in mice. It provides the biological rationale for developing drugs (senolytics) to do the same in humans, but the genetic method itself is not a human intervention.
ModerateSupportsMEDIUM confidence
The authors demonstrated that the animals treated with AP20187 from early (weaning time) or late (5 months) in life, had reduced numbers of p16Ink4a-positive senescent cells, and progression of p16Ink4a-mediated age-related phenotypes in adipose tissue and muscle was delayed (19).
Why this rating
Based on transgenic mouse models; highly controlled but not translatable directly to humans without significant modification.
Source
Senotherapeutics: emerging strategy for healthy aging and age-related disease
Eok-Cheon Kim et al. · BMB Reports · 2019
DOI 10.5483/bmbrep.2019.52.1.293
narrative_reviewCited 199×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Caloric restriction (CR) is the only intervention shown to increase health span and decrease the risk of age-related diseases in nonhuman primates.Good
- Pharmacological clearance of senescent cells using senolytics (specifically dasatinib and quercetin) extends health span and reduces age-related pathologies in mouse models.Moderate
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