Energy balance
Caloric restriction (CR) is the only intervention shown to increase health span and decrease the risk of age-related diseases in nonhuman primates.
Caloric restriction, specifically a 15% reduction in calories, has been shown to slow metabolic aging and reduce oxidative damage in humans over a 2-year period. It is the only intervention proven to extend health span in nonhuman primates. However, adherence is difficult, leading to interest in mimetics and fasting-mimicking diets.
Caloric restriction (CR) is the only intervention shown to increase health span as well as to decrease the risk of ARDs in nonhuman primates (5).
Why this rating
Based on nonhuman primate studies, which are closer to humans than mice, and includes human clinical trial data showing metabolic slowing.
Source
Senotherapeutics: emerging strategy for healthy aging and age-related disease
Eok-Cheon Kim et al. · BMB Reports · 2019
DOI 10.5483/bmbrep.2019.52.1.293
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