Mixed
Long-term instability of the intestinal microbiome is significantly associated with metabolic liver disease (FLD) and diabetes mellitus, characterized by an increase in facultative pathogens like Enterobacteriaceae and Escherichia/Shigella.
If you have metabolic liver disease or diabetes, your gut microbiome is likely less stable and may harbor more opportunistic pathogens. This instability is a marker of metabolic health rather than just a random fluctuation. Managing metabolic health may be key to maintaining microbiome stability.
The greatest microbiome instability was associated with factors contributing to metabolic syndrome such as fatty liver disease and diabetes mellitus. These, in turn, were associated with an increase in facultative pathogens such as Enterobacteriaceae or Escherichia/Shigella.
Why this rating
Large longitudinal cohort (n=1282) with paired samples and rigorous statistical correction, but observational design limits causal inference.
Source
Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function
Fabian Frost et al. · Gut · 2020
DOI 10.1136/gutjnl-2020-322753
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