Mixed
Microbiota instability and metabolic diseases like FLD and diabetes are linked to an increased predicted microbial potential for lipopolysaccharide (LPS) biosynthesis, which may trigger proinflammatory cytokines and aggravate metabolic disorders.
An unstable gut microbiome in the context of metabolic disease may lead to higher levels of bacterial components (LPS) that trigger inflammation. This suggests that managing gut health could potentially reduce inflammatory burden in metabolic disorders.
Correspondingly, the genetic microbial potential for the production of lipopolysaccharides (LPS) was increased at SHIP-3 compared with SHIP-2. ... LPS triggers the production of proinflammatory cytokines and can contribute to the development of FLD and diabetes mellitus.
Why this rating
Longitudinal data with predicted metagenomics and statistical association with disease states.
Source
Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function
Fabian Frost et al. · Gut · 2020
DOI 10.1136/gutjnl-2020-322753
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