Research
Mixed
The differential expression of immunity-related genes during aging is linked to the rate of aging, where long-lived organisms exhibit enhanced resistance to pathogens.
Genetic factors that enhance immune response in model organisms are associated with extended lifespan, suggesting a conserved link between immune fitness and longevity.
GoodSupportsHIGH confidence
Experimental alterations of longevity indicate that the differential expression of immunity-related genes during aging is linked to the rate of aging.
Why this rating
Supported by genetic studies in nematodes and Drosophila showing causal links between immune genes and lifespan.
Source
Immunity and aging: the enemy within?
Brian DeVeale et al. · Aging Cell · 2004
DOI 10.1111/j.1474-9728.2004.00106.x
narrative_reviewCited 172×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Aging is associated with a decline in adaptive immunity and a concurrent up-regulation of innate immunity, resulting in chronic inflammation.Good
- Blocking the expression of immune-related genes can prevent lifespan extension in long-lived nematodes, indicating a positive effect of the immune response on longevity.Good
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