Research
Mixed
Blocking the expression of immune-related genes can prevent lifespan extension in long-lived nematodes, indicating a positive effect of the immune response on longevity.
In model organisms, the immune system is not just for fighting infection but is actively required for extended lifespan, suggesting a trade-off between immune activation and aging.
GoodSupportsHIGH confidence
blocking the expression of immune-related genes can prevent lifespan extension.
Why this rating
Based on genetic knockout studies in C. elegans showing causal links.
Source
Immunity and aging: the enemy within?
Brian DeVeale et al. · Aging Cell · 2004
DOI 10.1111/j.1474-9728.2004.00106.x
narrative_reviewCited 172×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Aging is associated with a decline in adaptive immunity and a concurrent up-regulation of innate immunity, resulting in chronic inflammation.Good
- The differential expression of immunity-related genes during aging is linked to the rate of aging, where long-lived organisms exhibit enhanced resistance to pathogens.Good
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