Research
Mixed
Activation of the immune system can reduce longevity upon starvation, indicating a trade-off between beneficial and detrimental effects of immunity on aging.
While immune fitness may support longevity, chronic immune activation during metabolic stress (like starvation) can be harmful, highlighting the importance of context in immune health.
ModerateRefutesMEDIUM confidence
By contrast, it has been reported that activation of the immune system can reduce longevity upon starvation.
Why this rating
Based on reported studies, but the mechanism is less detailed than the positive links.
Source
Immunity and aging: the enemy within?
Brian DeVeale et al. · Aging Cell · 2004
DOI 10.1111/j.1474-9728.2004.00106.x
narrative_reviewCited 172×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
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