Research
Energy balance
In individuals with obesity, weight gain is associated with a higher risk of cardiovascular disease (CVD) compared to weight maintenance.
If you have obesity, avoiding weight gain is important for cardiovascular health. Gaining weight was associated with a higher risk of CVD compared to maintaining your current weight. Focus on strategies to maintain your current weight.
ModerateSupportsMEDIUM confidence
Among individuals with obesity, those in the weight gain group had a higher risk for CVD [HR =1.31 (1.07-1.60)], compared to those in the maintenance group.
Why this rating
Large sample size and robust statistical methods, but observational nature limits causal certainty.
Source
Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records
Michail Katsoulis et al. · Epidemiology · 2021
DOI 10.1097/ede.0000000000001393
preprint · n=138567Cited 33×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- In individuals with obesity, intentional or observed weight loss reduces the risk of coronary heart disease (CHD) and myocardial infarction compared to weight maintenance.Moderate
- In normal weight individuals, both weight loss and weight gain are associated with an increased risk of cardiovascular disease (CVD) compared to weight maintenance.Moderate
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