Mixed
An 18-week personalized dietary program (PDP) based on postprandial glucose, triglycerides, microbiome, and health history significantly reduces triglycerides, body weight, waist circumference, and HbA1c compared to standard USDA dietary guidelines.
Follow a personalized nutrition program that uses your body's specific response to food (glucose, triglycerides, microbiome) to guide your diet. This approach leads to greater improvements in triglycerides, weight loss, and blood sugar control compared to following standard government dietary guidelines alone. High adherence to the personalized advice is key to seeing these benefits.
Intention-to-treat analysis (n = 347) between groups showed significant reduction in TGs... There were improvements in secondary outcomes, including body weight, waist circumference, HbA1c, diet quality and microbiome (beta-diversity) (P < 0.05), particularly in highly adherent PDP participants.
Why this rating
Randomized controlled trial with intention-to-treat analysis, large sample size (n=347), and rigorous statistical adjustment.
Source
Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial
Kate Bermingham et al. · Nature Medicine · 2024
DOI 10.1038/s41591-024-02951-6
More from this paper
- High adherence to a personalized dietary program significantly reduces LDL cholesterol and apolipoprotein B, whereas standard dietary advice does not, suggesting personalization may be necessary for lipid management in certain individuals.Good
- A personalized dietary program favorably shifts gut microbiome composition, increasing the relative abundance of species associated with favorable cardiometabolic health, compared to standard dietary advice.Good
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