Research
Mixed
High adherence to a personalized dietary program significantly reduces LDL cholesterol and apolipoprotein B, whereas standard dietary advice does not, suggesting personalization may be necessary for lipid management in certain individuals.
If you have high cholesterol, a personalized diet that accounts for your specific biological response to food may be more effective at lowering LDL and ApoB than standard guidelines, provided you adhere closely to the personalized advice.
GoodQualifiesMEDIUM confidence
LDL-C was reduced in highly adherent PDP participants... Greater changes in outcomes were observed in adherent PDP versus adherent control groups for... apolipoprotein B (−7.94 ± 13.7 versus −1.14 ± 12.8 mg dl−1, P = 0.025) and total cholesterol (−0.40 ± 0.51 versus −0.13 ± 0.63 mmol l−1, P = 0.047)
Why this rating
Post-hoc subgroup analysis; while statistically significant, it is not the primary endpoint and requires high adherence.
Source
Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial
Kate Bermingham et al. · Nature Medicine · 2024
DOI 10.1038/s41591-024-02951-6
rct · n=347Cited 117×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- A personalized dietary program favorably shifts gut microbiome composition, increasing the relative abundance of species associated with favorable cardiometabolic health, compared to standard dietary advice.Good
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