Research
Energy balance
Body Mass Index (BMI) is a major confounder in studies linking macronutrient intake to mortality, and its exclusion from multivariate analysis in the PURE study is questionable.
When evaluating studies on diet and health, check if BMI was included as a confounder. Its absence may skew results, as BMI is strongly linked to both diet and mortality.
GoodQualifiesHIGH confidence
BMI is a major confounder when studying the association between food intake and mortality... Thus, we question why the authors used waist-to-hip ratio rather than BMI as a covariate in the multivariate analysis.
Why this rating
Based on established epidemiological principles regarding BMI and mortality.
Source
Associations of fats and carbohydrates with cardiovascular disease and mortality—PURE and simple?
Xi‐Peng Cao et al. · The Lancet · 2018
DOI 10.1016/s0140-6736(18)30793-1
narrative_reviewCited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Food Frequency Questionnaires (FFQs) are error-prone for estimating fat intake, particularly for edible oils in Chinese populations, leading to potential inaccuracies in the PURE study's conclusions.Good
- High carbohydrate intake is associated with increased total mortality, while high intake of total fat and individual types of fat is associated with reduced total mortality.Moderate
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