Research
Energy balance
Moderate (~10%) weight loss improves systemic cardiometabolic risk factors (plasma insulin and arterial stiffness) similarly in both childhood-onset (CO) and adult-onset obesity (AO) populations.
Losing about 10% of your body weight through diet and exercise significantly improves your blood vessel health (arterial stiffness) and insulin sensitivity, regardless of whether you became obese as a child or as an adult. This is a robust benefit of weight loss that applies to everyone with obesity.
ModerateSupportsMEDIUM confidence
Across groups, plasma insulin concentration decreased 1.33-fold... and arterial stiffness decreased by 0.64 m/s...
Why this rating
Small sample size, but clear statistical significance for systemic markers.
Source
The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss
Jessica Murphy et al. · Frontiers in Immunology · 2025
DOI 10.3389/fimmu.2025.1601847
clinical_trial · n=27Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Moderate (~10%) weight loss achieved through diet and exercise reduces pro-inflammatory M1-like macrophages in abdominal subcutaneous adipose tissue (SAT) in adults with adult-onset obesity (AO), but fails to alter these immune cell profiles in those with childhood-onset obesity (CO).Moderate
- Moderate weight loss increases CD3+CD4+ T cells in both abdominal and femoral subcutaneous adipose tissue in adults with adult-onset obesity (AO), but not in those with childhood-onset obesity (CO).Moderate
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