Research
Cellular
Gastrointestinal adverse events were more frequent with semaglutide (82.8%) compared to placebo (63.2%).
Clinicians should monitor for gastrointestinal side effects when prescribing semaglutide.
StrongSupportsmedium confidence
Gastrointestinal adverse events were more frequent with semaglutide (82.8%) vs placebo (63.2%).
Why this rating
Based on a randomized, double-blind, parallel-group, phase 3a study design.
Source
Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity
Thomas A. Wadden et al. · JAMA · 2021
DOI 10.1001/jama.2021.1831
rct · n=611Cited 983×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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