Research
Energy balance
Treatment with tirzepatide resulted in a least-squares mean percent change in weight of -20.2% at week 72, compared to -13.7% with semaglutide.
Tirzepatide may be a more effective option for weight loss in obese adults without diabetes.
StrongSupportsmedium confidence
The least-squares mean percent change in weight at week 72 was -20.2% with tirzepatide and -13.7% with semaglutide (P<0.001).
Why this rating
Based on study design from abstract.
Source
Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
Louis J. Aronne et al. · New England Journal of Medicine · 2025
rct · n=751Cited 389×
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