Research
Energy balance
Tirzepatide led to a least-squares mean change in waist circumference of -18.4 cm, while semaglutide led to -13.0 cm.
Tirzepatide may also be beneficial for reducing waist circumference in obese adults without diabetes.
StrongSupportsmedium confidence
The least-squares mean change in waist circumference was -18.4 cm with tirzepatide and -13.0 cm with semaglutide (P<0.001).
Why this rating
Based on study design from abstract.
Source
Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
Louis J. Aronne et al. · New England Journal of Medicine · 2025
DOI 10.1056/nejmoa2416394
rct · n=751Cited 389×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Treatment with tirzepatide resulted in a least-squares mean percent change in weight of -20.2% at week 72, compared to -13.7% with semaglutide.Strong
- Participants in the tirzepatide group were more likely to achieve weight reductions of at least 10%, 15%, 20%, and 25% compared to the semaglutide group.Strong
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