Research
Energy balance
Tirzepatide led to a least-squares mean change in waist circumference of -18.4 cm, while semaglutide led to -13.0 cm.
Tirzepatide may also be beneficial for reducing waist circumference in obese adults without diabetes.
StrongSupportsmedium confidence
The least-squares mean change in waist circumference was -18.4 cm with tirzepatide and -13.0 cm with semaglutide (P<0.001).
Why this rating
Based on study design from abstract.
Source
Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
Louis J. Aronne et al. · New England Journal of Medicine · 2025
rct · n=751Cited 389×
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