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Participants in the tirzepatide group were more likely to achieve weight reductions of at least 10%, 15%, 20%, and 25% compared to the semaglutide group.
Tirzepatide may provide a higher chance of achieving significant weight loss milestones in obese adults without diabetes.
StrongSupportsmedium confidence
Participants in the tirzepatide group were more likely than those in the semaglutide group to have weight reductions of at least 10%, 15%, 20%, and 25%.
Why this rating
Based on study design from abstract.
Source
Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
Louis J. Aronne et al. · New England Journal of Medicine · 2025
DOI 10.1056/nejmoa2416394
rct · n=751Cited 389×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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