Research
Energy balance
Participants in the tirzepatide group were more likely to achieve weight reductions of at least 10%, 15%, 20%, and 25% compared to the semaglutide group.
Tirzepatide may provide a higher chance of achieving significant weight loss milestones in obese adults without diabetes.
StrongSupportsmedium confidence
Participants in the tirzepatide group were more likely than those in the semaglutide group to have weight reductions of at least 10%, 15%, 20%, and 25%.
Why this rating
Based on study design from abstract.
Source
Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
Louis J. Aronne et al. · New England Journal of Medicine · 2025
rct · n=751Cited 389×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →