Research
Energy balance
Tirzepatide at doses of 5 mg, 10 mg, or 15 mg once weekly resulted in a mean percentage change in weight of -15.0%, -19.5%, and -20.9% respectively at week 72.
Tirzepatide is effective for significant weight loss in adults with obesity.
StrongSupportsmedium confidence
The mean percentage change in weight at week 72 was -15.0% (95% confidence interval [CI], -15.9 to -14.2) with 5-mg weekly doses of tirzepatide, -19.5% (95% CI, -20.4 to -18.5) with 10-mg doses, and -20.9% (95% CI, -21.8 to -19.9) with 15-mg doses.
Why this rating
Based on the large randomized controlled trial design.
Source
Tirzepatide Once Weekly for the Treatment of Obesity
Ania M. Jastreboff et al. · New England Journal of Medicine · 2022
DOI 10.1056/nejmoa2206038
rct · n=2539Cited 3,092×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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