Research
Energy balance
85%, 89%, and 91% of participants achieved a weight reduction of 5% or more with 5 mg, 10 mg, and 15 mg of tirzepatide respectively.
A high percentage of adults with obesity can expect significant weight loss with tirzepatide.
StrongSupportsmedium confidence
The percentage of participants who had weight reduction of 5% or more was 85% (95% CI, 82 to 89), 89% (95% CI, 86 to 92), and 91% (95% CI, 88 to 94) with 5 mg, 10 mg, and 15 mg of tirzepatide, respectively.
Why this rating
Based on the large randomized controlled trial design.
Source
Tirzepatide Once Weekly for the Treatment of Obesity
Ania M. Jastreboff et al. · New England Journal of Medicine · 2022
DOI 10.1056/nejmoa2206038
rct · n=2539Cited 3,092×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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