Research
Cellular
The most common adverse events with tirzepatide were gastrointestinal, primarily mild to moderate in severity.
Practitioners should monitor for gastrointestinal side effects in patients using tirzepatide.
StrongSupportsmedium confidence
The most common adverse events with tirzepatide were gastrointestinal, and most were mild to moderate in severity.
Why this rating
Based on the large randomized controlled trial design.
Source
Tirzepatide Once Weekly for the Treatment of Obesity
Ania M. Jastreboff et al. · New England Journal of Medicine · 2022
DOI 10.1056/nejmoa2206038
rct · n=2539Cited 3,092×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Tirzepatide at doses of 5 mg, 10 mg, or 15 mg once weekly resulted in a mean percentage change in weight of -15.0%, -19.5%, and -20.9% respectively at week 72.Strong
- 85%, 89%, and 91% of participants achieved a weight reduction of 5% or more with 5 mg, 10 mg, and 15 mg of tirzepatide respectively.Strong
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