Research
Energy balance
Once-weekly subcutaneous semaglutide resulted in a mean weight change of -15.8% compared to -6.4% with once-daily subcutaneous liraglutide at 68 weeks.
Semaglutide may be more effective than liraglutide for weight loss in this population.
StrongSupportsmedium confidence
The mean weight change from baseline was -15.8% with semaglutide vs -6.4% with liraglutide.
Why this rating
Based on a randomized, open-label, phase 3b trial design.
Source
Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes
Domenica M. Rubino et al. · JAMA · 2022
rct · n=338Cited 856×
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