Research
Energy balance
Participants had significantly greater odds of achieving 10% or more weight loss with semaglutide compared to liraglutide (70.9% vs 25.6%).
Semaglutide may offer a higher likelihood of significant weight loss compared to liraglutide.
StrongSupportsmedium confidence
Participants had significantly greater odds of achieving 10% or more...with semaglutide vs liraglutide (70.9% of participants vs 25.6%).
Why this rating
Based on a randomized, open-label, phase 3b trial design.
Source
Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes
Domenica M. Rubino et al. · JAMA · 2022
DOI 10.1001/jama.2021.23619
rct · n=338Cited 856×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Once-weekly subcutaneous semaglutide resulted in a mean weight change of -15.8% compared to -6.4% with once-daily subcutaneous liraglutide at 68 weeks.Strong
- The proportion of participants discontinuing treatment for any reason was lower with semaglutide (13.5%) compared to liraglutide (27.6%).Strong
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