Research
Metabolic adaptation
Each 5-unit increment in BMI was associated with a 20% increased risk of early-onset CRC (RR 1.20).
Weight management strategies may be important for reducing early-onset CRC risk.
StrongSupportsmedium confidence
The RR for each 5-unit increment in BMI was 1.20 (95% CI, 1.05-1.38; P = .01 for trend).
Why this rating
Based on a large prospective cohort study design.
Source
Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women
Po‐Hong Liu et al. · JAMA Oncology · 2018
DOI 10.1001/jamaoncol.2018.4280
cohort · n=85256Cited 514×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Obesity was associated with an increased risk of early-onset colorectal cancer (CRC) among women, with a multivariable relative risk (RR) of 1.93 for obese women (BMI ≥30.0).Strong
- Weight gain since 18 years of age is associated with an increased risk of early-onset CRC, with a RR of 2.15 for women gaining 40.0 kg or more.Strong
Related findings · Metabolic adaptation
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →