Research
Metabolic adaptation
Each 5-unit increment in BMI was associated with a 20% increased risk of early-onset CRC (RR 1.20).
Weight management strategies may be important for reducing early-onset CRC risk.
StrongSupportsmedium confidence
The RR for each 5-unit increment in BMI was 1.20 (95% CI, 1.05-1.38; P = .01 for trend).
Why this rating
Based on a large prospective cohort study design.
Source
Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women
Po‐Hong Liu et al. · JAMA Oncology · 2018
cohort · n=85256Cited 514×
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