Research
Metabolic adaptation
Weight gain since 18 years of age is associated with an increased risk of early-onset CRC, with a RR of 2.15 for women gaining 40.0 kg or more.
Monitoring weight gain in young women may help in early CRC risk assessment.
StrongSupportsmedium confidence
Compared with women who had gained less than 5.0 kg or had lost weight, the RR of early-onset CRC was 2.15 (95% CI, 1.01-4.55) for women gaining 40.0 kg or more.
Why this rating
Based on a large prospective cohort study design.
Source
Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women
Po‐Hong Liu et al. · JAMA Oncology · 2018
cohort · n=85256Cited 514×
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