Research
Molecular
Reduction of PLA2G7 may mediate the immunometabolic effects of caloric restriction and could potentially lower inflammation and extend health span.
Targeting PLA2G7 may be a strategy to reduce inflammation and improve health span.
StrongSupportsmedium confidence
Therefore, the reduction of PLA2G7 may mediate the immunometabolic effects of CR and could potentially be harnessed to lower inflammation and extend the health span.
Why this rating
The findings are based on both human and animal studies.
Source
Caloric restriction in humans reveals immunometabolic regulators of health span
Olga Spadaro et al. · Science · 2022
cohortCited 297×
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