Research
Cellular
About 14% caloric restriction for 2 years in healthy humans improved thymopoiesis.
Caloric restriction may enhance immune function in healthy individuals.
StrongSupportsmedium confidence
We report that about 14% CR for 2 years in healthy humans improved thymopoiesis.
Why this rating
The study involves human subjects over a significant duration.
Source
Caloric restriction in humans reveals immunometabolic regulators of health span
Olga Spadaro et al. · Science · 2022
DOI 10.1126/science.abg7292
cohortCited 297×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Caloric restriction-induced transcriptional reprogramming in adipose tissue implicated pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity.Strong
- Reduction of PLA2G7 may mediate the immunometabolic effects of caloric restriction and could potentially lower inflammation and extend health span.Strong
Related findings · Cellular
- Athletes aiming to reduce fat mass and preserve FFM should consume protein intakes in the range of ∼1.8-2.7 g kg(-1) d(-1).Strong
- A minimum daily protein intake of ≥1.6 g/kg is necessary to observe significant improvements in muscle mass from whey protein supplementation.Strong
- Most athletes ideally need 1.2 to 2.0 grams/kg of body weight/day of protein, preferably split across 3-4 meals.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →