Research
Cellular
Insulin action has a familial component, with heritability estimates ranging from 0.38 to 0.61 depending on conditions.
Understanding insulin action's genetic basis can aid in diabetes prevention strategies.
StrongSupportsmedium confidence
38%-49% of the variance in insulin action, independent of the effect of obesity, is familial.
Why this rating
The study provides clear heritability estimates based on a defined methodology.
Source
Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians.
H. Sakul et al. · PubMed · 1997
otherCited 111×
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