Research
Cellular
Elderly adults have reduced mitochondrial capacity and a trend for decreased coupling efficiency compared to young adults.
Practitioners should consider the impact of aging on mitochondrial function when addressing metabolic health in elderly populations.
ModerateSupportsmedium confidence
Elderly volunteers had reduced mitochondrial capacity (P = 0.05) and a trend for decreased coupling efficiency (P = 0.08) despite similar mitochondrial content and fiber type distribution.
Why this rating
The study design is cross-sectional, which provides a snapshot but not causal relationships.
Source
Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity
Darcy L. Johannsen et al. · The Journal of Clinical Endocrinology & Metabolism · 2011
DOI 10.1210/jc.2011-1798
cross-sectional · n=29Cited 106×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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