Mixed
In patients with new-onset type 2 diabetes, a weight loss of 10% or more within the first two years is associated with the highest risk of all-cause mortality.
If you have recently been diagnosed with type 2 diabetes, avoid losing more than 10% of your body weight in the first two years. Significant weight loss in this context is linked to higher mortality, possibly due to muscle loss or other health issues. Focus on maintaining a stable weight rather than aggressive weight loss.
The group with weight loss ≥ − 10% had the highest HR for all-cause mortality (HR, 1.86; 95% CI 1.61–2.14)
Why this rating
Large nationwide cohort (n=173,246) with rigorous exclusion of prior cancer/CVD, though observational design limits causal inference.
Source
Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
Mee Kyoung Kim et al. · Cardiovascular Diabetology · 2019
DOI 10.1186/s12933-019-0838-9
More from this paper
- In patients with new-onset type 2 diabetes, a weight gain of 10% or more within the first two years is associated with an increased risk of stroke.Good
- In patients with new-onset type 2 diabetes, weight change (gain or loss) of more than 10% is associated with higher all-cause mortality compared to stable weight.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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